Goserelin
Goserelin is a synthetic hormone. In men, it stops the production of the hormone
testosterone, which may stimulate the growth of cancer cells. In women, goserelin
decreases the production of the hormone estradiol (which may stimulate the growth of
cancer cells) to levels similar to a postmenopausal state. When the medication is stopped,
hormone levels return to normal
Goserelin is used to treat:
- prostate cancer
- endometriosis
- advanced breast cancer in premenopausal and perimenopausal women
Side effects of Goserelin
Each person's reaction to any medication is unique. Many people have very few side
effects with goserelin, while others may experience more. We have outlined the most common
side effects, so that you can be aware of them if they occur. However, we have not
included those that are very rare and therefore extremely unlikely to affect you. If you
do notice any effects which you think may be due to the drug, but which are not listed,
please discuss these with your doctor or nurse.
You will see your doctor regularly while you have this treatment so that they can
monitor the effects. This information should help you to discuss any queries about your
treatment and its side effects with your doctor or nurse, as they are in the best position
to help and advise you.
Menstruation. Women taking goserelin usually find that their periods
stop while they are having this treatment. This is an expected effect and is due to the
lowered levels of oestrogen in the body. When the goserelin is stopped, periods will
usually start again. However, if a woman was nearing the age of menopause when she began
the treatment, her periods may not return when the treatment stops. Although periods have
stopped, goserelin is not a contraceptive drug, and women need to ensure that they use
effective forms of contraception while having goserelin treatment. It is helpful to
discuss this with your doctor.
Some people may have some of the following side effects:
Tumour flare. There may be a temporary increase in the levels of
oestrogen for the first few days or weeks of starting goserelin. Because of this, some
people may find that they have an increase in symptoms, such as an increase in the size of
their tumour. If you experience any problems, you will need to let your doctor know.
Hot flushes. These can be quite common. Many women find that the hot
flushes wear off after a period of time and become less of a problem. There are a number
of ways to help reduce or control hot flushes and sweats. Some people find it is helpful
to cut down on tea, coffee, nicotine and alcohol. Recent research suggests that
progesterone or some anti-depressants may be very helpful in controlling this side effect.
Some women have found complementary therapies helpful, and your GP may be able to give you
details about obtaining these on the NHS.
Loss of libido (sex drive). Many women experience a lowering of their
sex drive whilst having treatment with goserelin which normally continues for as long as
the treatment is given. Some women also have vaginal dryness. Gels can help to counteract
the dryness and these are available from a chemist or can be prescribed by your doctor.
Your doctor or nurse can discuss this with you. .
Breast tenderness or fullness. You may also notice some swelling of
your breasts.
Skin rashes. Some people have skin rashes. Let your doctor know if
this occurs.
Sore joints. Some people may have soreness in their joints, but this
is usually mild and will stop when the treatment is finished.
Weight gain and tiredness. You may notice that you gain a few pounds
in weight and may feel less energetic than usual. This usually subsides when the goserelin
treatment is stopped.
Nausea (feelings of sickness). Let your doctor know if you have nausea
as medication can be prescribed to help.
Headaches and mood changes. These are uncommon, but some people may
find that they feel low in mood, or have headaches while having goserelin treatment. |