Exemestane
Exemestane is a medicine that is used to treat breast cancer in women whose disease has
progressed while they were taking tamoxifen.
Many breast cancers rely on the hormone oestrogen to grow. In women who have passed the
menopause the main source of oestrogen is through the conversion of androgens (sex
hormones produced by the adrenal glands) into oestrogens. This is carried out by an enzyme
called aromatase. This conversion process is known as aromatisation, and happens mainly in
the fatty tissues of the body.
Exemestane works by blocking this process and preventing this chemical change. This
results in a reduction in the amount of oestrogen in the body. For this reason exemestane
is known as an aromatase inhibitor.
Side effects of Exemestane
Each person's reaction to any medication is unique. Most people have very few side
effects with exemestane, while others may experience more. The side effects described here
will not affect everyone and may be different if you are having more than one drug.
We have outlined the most common side effects, so that you can be aware of them if they
occur. However, we have not included those that are very rare and therefore extremely
unlikely to affect you. If you do notice any effects which you think may be due to the
drug, but which are not listed, please discuss these with your doctor or nurse.
You will see your doctor regularly while you have this treatment so that they can
monitor the effects. This information should help you to discuss any queries about
your treatment and its side effects with your doctor or nurse, as they are in the best
position to help and advise you.
Some people may have the following side effects to varying degrees. If any side effects
do occur they are usually mild.
Hot flushes and increased sweating. These are usually mild and may
wear off after a period of time and become less of a problem. Sometimes women find that
avoiding or cutting down on tea, coffee, nicotine and alcohol can reduce sweats. Recent
research suggests that progesterone or some anti-depressants may be very helpful in
controlling this side effect. Some women find that complementary therapies have helped,
and your GP may be able to give you details about obtaining these on the NHS. If you are
having troublesome hot flushes do not hesitate to discuss it with your doctor.
Nausea (feeling of sickness). If this occurs it can usually be
effectively treated so let your doctor know. Feelings of sickness can often be relieved by
taking your tablet with food or at night.
Fatigue (feeling of tiredness). This is not a common problem but if it
occurs it is important to get plenty of rest. .
Dizziness and headaches. This is not common but it is important to let
your doctor know if you have these symptoms as medication can be prescribed to help.
Abdominal pain and diarrhoea. Rarely exemestane can cause diarrhoea.
If this occurs it is important to inform your doctor as medication can be prescribed to
help. It is also important to drink plenty of fluids.
Hair thinning. Some women notice their hair becomes thinner while
taking exemestane. This is usually mild and the hair goes back to normal at the end of
treatment. |